影片讲述了刚步入青春期的小女孩莱莉脑海中的复杂情绪进行的一场奇妙冒险。在她的大脑总部，正经历着一场突如其来的大拆迁，为意想不到的新情绪腾出空间。一直以来配合默契的情绪小伙伴乐乐（艾米·波勒 Amy Poehler 配音）、忧忧（菲利丝·史密斯 Phyllis Smith 配音）、怒怒（刘易斯·布莱克 Lewis Black 配音）、怕怕（托尼·海尔 Tony Hale 配音）和厌厌（莉萨·拉皮拉 Liza Lapira 配音），在新情绪焦焦的突然到来时变得不知所措，并且她看起来不是孤身一人。...
California gold rush, late 1800's: A gun slinging bounty hunter (Mortimer) travels deep into the mountains to find a deadly Apache warrior (Brother Wolf) who is wanted by the law. Along the way he passes through a gold mining Town. The miners help direct Mortimer to the Apache and send him on his way.
Mortimer enters the forest and begins to track the Apache. Back in town, the miners un-earth an ancient meteor. They use their pick axes to crack it open. A section of the meteor splits apart and spores explode out of it. The spore surround and infect the entire population of the mining camp. They are transformed into ravenous mutants.
After a vicious battle against the Apache warrior, Mortimer exits the forest with his prisoner in shackles. They hike back to the mining town to find them selves surrounded by a horde of blood thirsty mutants. Now Mortimer the gun slinger and Brother Wolf the Warrior must join together to survive the mutant hordes. What ensues is a bloodbath of horror for the Dead and the Damned....
